Running blockchain infrastructure: node deployment and sync, RPC endpoints, indexers and subgraphs, data pipelines, monitoring and cost control.
Include chain, client, version and hardware when asking about sync, storage growth or performance. Those details determine the answer.
Comparisons between self-hosted and managed infrastructure are welcome, including the operational time each really costs.
Choosing a commercial provider is covered in RPC, Nodes, APIs, DevOps & Web3 Infrastructure.